COVID-19 Clinical Resources and Pertinent Research
A daily updated list of the most useful COVID-19 clinical resources and the most significant research publications with a summary of their key findings. To contribute, click the plus button on the left. Short URL: bit.ly/C19Res

Epidemiology and Virology

  1. General Epidemiology
    1. CEBM: Global COVID-19 Case Fatality Rates
    2. Cochrane COVID-19 Reviews of Infection Prevention and Control Measures
    3. Imperial College London Centre for Global Infection Disease Analysis COVID-19 Reports
    4. Recurrent Outbreaks (“Second and Third Waves”) Are Likely
    5. COVID-19 Symptomatic Infection Fatality Rate (IFR-S) in the U.S. is 0.8–1.3% and the Case Fatality Rate (CFR) is ~6%
    6. Seroprevalence of SARS-CoV-2–Specific Antibodies Among Adults Remains Very Low
    7. SARS-COV-2 Clusters Have Been Traced to Parties, Nightclubs, Bars, Karaoke Bars, and Gyms
    8. Testing of Sewage May Be Useful in Monitoring and Predicting Infection Rates

  2. Vaccine Development
    1. The Lancet: COVID-19 Vaccine Development Update (June 2020)
    2. STAT News COVID-19 Vaccine Tracker

  3. Viral Transmission and Shedding
    1. SARS-CoV-2 is Shed During Respiration, Toileting, and Fomite Contact and Can Be Aerosolized
    2. SARS-CoV-2 Can Remain Viable and Infectious in Aerosols for Hours and on Surfaces for Days
    3. The Mean Incubation Period of COVID-19 is 5 Days
    4. Detection of Viral RNA via PCR in Recovered Individuals Does Not Indicate Infectiousness
    5. Upper Respiratory Viral Shedding Peaks 4-6 Days After Symptom Onset / Viral Load May Correlate with Severity
    6. SARS-CoV-2 is Transmitted by Asymptomatic and Presymptomatic Individuals
    7. Symptomatic Neonates, Children, and Teenagers Shed Infectious SARS-CoV-2
    8. SARS-CoV-2 is Consistently Found in Stool, Indicating Potential for Fecal-Oral Transmission
    9. No Evidence that Seasonality or Warmer Temperatures Reduce Transmission of SARS-CoV-2
  4. Viral Dynamics and Immune Response
    1. General
    2. Humans Produce Neutralizing Antibodies to SARS-CoV-2
    3. Neutralization Antibody Titers Correlate with the Numbers of Virus-specific T Cells
    4. Asymptomatic SARS-CoV-2 Infections May Be Associated with a Weaker Concomitant Immune Response
    5. Natural Passive Immunity without Vertical Transmission Has Been Observed in Several Newborns
    6. Duration of Postinfection Immunity

  5. Virology
    1. Genomic Epidemiology of SARS-CoV-2
    2. Video Lecture: Molecular Virology of Coronaviruses
    3. Structures, Conformations, and Distributions of SARS-CoV-2 Spike Protein Trimers (Not Peer Reviewed)
    4. Mutations in the SARS-CoV-2 Spike Protein
    5. SARS-CoV-2 was Introduced to the NYC Area Mainly from Europe and Other Parts of the United States
    6. SARS-CoV-2 was Introduced into California via 7 Different Lineages, Including the Strains Associated with Washington State, with No Predominant Lineage and Limited Transmission Between Communities
    7. Neuropilin-1 (NRP1) Appears to be a Host Factor for SARS-CoV-2
    8. SARS-CoV-2 is Not a Purposefully Manipulated Virus

  6. Other
    1. Pts <60 with a BMI of 30-34 are 2.0x and 1.8x More Likely to be Admitted to Acute and Critical Care, Respectively
    2. BCG Vaccine May Possibly Be Protective Against SARS-CoV-2
    3. SARS-CoV-2 May Persist in Semen Even if it Cannot Replicate
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