COVID-19 Clinical Resources and Pertinent Research
A daily updated list of the most useful COVID-19 clinical resources and the most significant research publications with a summary of their key findings. To contribute, click the plus button on the left. Short URL:

Epidemiology and Virology

  1. General Epidemiology
    1. CEBM: Global COVID-19 Case Fatality Rates
    2. Cochrane COVID-19 Reviews of Infection Prevention and Control Measures
    3. Imperial College London Centre for Global Infection Disease Analysis COVID-19 Reports
    4. Recurrent Outbreaks (“Second and Third Waves”) Are Likely
    5. COVID-19 Symptomatic Infection Fatality Rate (IFR-S) in the U.S. is 0.8–1.5% and the Case Fatality Rate (CFR) is ~6%
    6. Seroprevalence of SARS-CoV-2–Specific Antibodies Among Adults Remains Very Low
    7. SARS-COV-2 Clusters Have Been Traced to Parties, Nightclubs, Bars, Karaoke Bars, and Gyms
    8. Testing of Sewage May Be Useful in Monitoring and Predicting Infection Rates

  2. Vaccine Development
    1. The Lancet: COVID-19 Vaccine Development Update (June 2020)
    2. NYT Coronavirus Vaccine Tracker
    3. STAT News COVID-19 Vaccine Tracker

  3. Viral Transmission and Shedding
    1. CEBM Papers on the Transmission Dynamics of COVID-19
    2. SARS-CoV-2 is Shed During Respiration, Toileting, and Fomite Contact and Can Be Aerosolized
    3. SARS-CoV-2 Can Remain Viable and Infectious in Aerosols for Hours and on Surfaces for Days
    4. The Mean Incubation Period of COVID-19 is 5 Days
    5. Detection of Viral RNA via PCR Does Not Necessarily Indicate Infectiousness
    6. Viral Load Peaks in the Early Phase with Upper Respiratory Viral Shedding Peaking 4-6 Days After Symptom Onset
    7. SARS-CoV-2 is Transmitted by Asymptomatic and Presymptomatic Individuals
    8. Symptomatic Neonates, Children, and Teenagers Shed Infectious SARS-CoV-2
    9. SARS-CoV-2 is Consistently Found in Stool, Indicating Potential for Fecal-Oral Transmission
    10. No Evidence that Seasonality or Warmer Temperatures Reduce Transmission of SARS-CoV-2
  4. Viral Dynamics and Immune Response
    1. General
    2. Humans Produce Neutralizing Antibodies to SARS-CoV-2
    3. Asymptomatic SARS-CoV-2 Infections May Be Associated with a Weaker Concomitant Immune Response
    4. SARS-CoV-2 T Cell Immunity and Relationship with Neutralization Antibody Titers
    5. Infection with Betacoronaviruses Induces Multispecific and Long-Lasting T Cell Immunity to the Structural Nucleocapsid Protein, that Appears to Neutralize SARS-CoV-2
    6. Natural Passive Immunity without Vertical Transmission Has Been Observed in Several Newborns
    7. Duration of Postinfection Immunity

  5. Virology
    1. Genomic Epidemiology of SARS-CoV-2
    2. Video Lecture: Molecular Virology of Coronaviruses
    3. Structures, Conformations, and Distributions of SARS-CoV-2 Spike Protein Trimers (Not Peer Reviewed)
    4. Mutations in the SARS-CoV-2 Spike Protein
    5. SARS-CoV-2 was Introduced to the NYC Area Mainly from Europe and Other Parts of the United States
    6. SARS-CoV-2 was Introduced into California via 7 Different Lineages, Including the Strains Associated with Washington State, with No Predominant Lineage and Limited Transmission Between Communities
    7. Neuropilin-1 (NRP1) Appears to be a Host Factor for SARS-CoV-2
    8. SARS-CoV-2 is Not a Purposefully Manipulated Virus and it’s Lineage has been Circulating in Bats for Decades

  6. Other
    1. Pts <60 with a BMI of 30-34 are 2.0x and 1.8x More Likely to be Admitted to Acute and Critical Care, Respectively
    2. Smoking Appears to Significantly Increase the Risk of Severe COVID-19 in Young Adults Aged 18-25
    3. Factors Associated with Death in COVID-19 Include Older Age, Male Sex, Obesity, Coronary Artery Disease, Cancer, and Acute Organ Dysfunction
    4. SARS-CoV-2 RNA Has Been Detected in Human Breastmilk, it Remains Unclear if this is Live Virus or Viral Fragments
    5. SARS-CoV-2 May Persist in Semen Even if it Cannot Replicate

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