COVID-19 Clinical Resources and Pertinent Research
A regularly updated list of the most useful COVID-19 clinical resources, the most significant research publications, and reliable news. To contribute, click the plus button on the left. Short URL: bit.ly/C19Res

Clinical Considerations

  1. General
    1. NEJM: Mild or Moderate COVID-19 (Diagram)
    2. Medium-Term Effects of SARS-CoV-2 Infection on Multiple Vital Organs, Exercise Capacity, Cognition, Quality of Life and Mental Health, Post-Hospital Discharge (Not Peer Reviewed)
    3. Extrapulmonary Manifestations of COVID-19

  2. Cardiovascular Involvement
  3. Pediatrics
  4. Coagulopathy (Pathophysiology Diagram)
    1. VTE Prevalence in COVID-19 is ~8% in non-ICU Patients and ~23% in ICU Patients; PE Prevalence is ~4% and ~14% in non-ICU and ICU Patients, Respectively
    2. Elevated D-dimer and Coagulopathy are Commonly Associated with Severe Clinical Manifestations of COVID-19
    3. Systemic Anticoagulation May Improve Survival in COVID-19

  5. Prognostic Indicators and Biomarkers
    1. Elevated IL-6 and TNF-α May Be Predictors of Respiratory Failure in Severe COVID-19
    2. Obesity and Fasting Blood Glucose Predict Mortality in Patients with COVID-19 Independent of Diabetes History
    3. Increased Neutrophil Activators (G-CSF, IL-8) and Effectors (RETN, LCN2, HGF, MMP8) are Hallmarks of Critical Illness in COVID-19
    4. Type-I Interferon Deficiency (No IFN-β and Low IFN-α) May Be a Hallmark of Severe COVID-19
    5. Calprotectin Levels Appear to Positively Correlate with Disease Severity
    6. Thrombocytopenia Appears to be Associated with Increased Disease Severity and Higher Mortality in COVID-19
    7. Abnormal Liver Tests Occur in Most Hospitalized COVID-19 Patients and May Be Associated with Worse Outcomes
    8. Elevated and Increasing Red Blood Cell Distribution Width at Admission May Be Associated with a Higher Mortality Risk for Patients with SARS-CoV-2
  6. Renal Involvement (Infographic)
    1. AKI Occurs in 26-32% of Hospitalized COVID-19 Patients and is Associated with a 3-Fold Increase in Mortality

  7. Neuro Involvement
    1. Guillain-Barré Syndrome Associated with SARS-Cov-2 Infection
    2. Indirect Neurological Complications (Confusion, Headache, etc.) Are Common; Acute Cerebrovascular Disease and Seizures Due to Dysregulation of Systemic Heomeostasis and Coagulopathy Have Been Observed; There is Little Evidence of Direct Neurological Involvement

  8. GI Involvement
    1. Digestive Symptoms Are Common in COVID-19 and May Be Associated with a Worse Prognosis
    2. Acute Mesenteric Ischemia from Small Vessel Thrombosis and Cholestasis are Common in COVID-19 Inpatients
    3. Role of PPIs

  9. Dermatologic Involvement
    1. Common Cutaneous Manifestations of COVID-19 Include Chilblain-like, Maculopapular, Vesicular, Urticarial, and Other Lesions and Nondescript Rashes
    2. Cutaneous Lesions are Most Commonly Seen on the Toes, Soles, Fingers, Extremities, and/or Heels (“COVID Toes”)

  10. Chemosensory Dysfunction
    1. Chemosensory Dysfunction, including Anosmia and/or Ageusia, is Strongly Associated with COVID‐19 and May Be Associated with Mild Disease
  11. OB/GYN Considerations
    1. Pregnant Women Appear to Have More Severe Illness Requiring Intensive Care and Mechanical Ventilation, and Severe COVID-19 in Pregnancy is Associated with Increased Age, Hypertension, Preexisting Diabetes, and High BMI
    2. Maternal SARS-CoV-2 Infection in Pregnancy is Not Associated with Adverse Pregnancy Outcomes; Neonatal Infection Occur in 3% of Infants
    3. Separation of Affected Mothers and Newborns May Not Be Warranted, and Direct Breastfeeding Appears to Be Safe
  12. Multisystem Inflammatory Syndrome in Adults (MIS-A)
    1. Adults of All Ages with Current or Previous SARS-CoV-2 Infection Can Develop a Hyperinflammatory Syndrome Resembling MIS-C
    2. For information on Multisystem Inflammatory Syndrome in Children (MIS-C), see Pediatrics
  13. Other
    1. Use of NSAIDs in Patients with COVID-19 is Safe and Does Not Lead to More Severe Disease
    2. Trained Immunity: A Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection
    3. Critically Ill COVID-19 Patients with Blood Group A or AB Appear to Be at Increased Risk for Mechanical Ventilation and More Severe Disease than Patients with Blood Group O or B; Further Research Is Needed to Determine if Anti-A Antibody Inhibits the Interaction between SARS-CoV-2 and the ACE2 Receptor
    4. Additional Extrapulmonary Manifestations
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