COVID-19 Clinical Resources and Pertinent Research
A daily updated list of the most useful COVID-19 clinical resources and the most significant research publications with a summary of their key findings. To contribute, click the plus button on the left. Short URL: bit.ly/C19Res

Clinical Considerations

  1. Extrapulmonary Manifestations of COVID-19
  2. Cardiovascular Involvement
  3. Pediatrics
  4. Coagulopathy
    1. Elevated D-dimer and Coagulopathy are Commonly Associated with Severe Clinical Manifestations of COVID-19
    2. Systemic Anticoagulation May Imrpove Survival in COVID-19

  5. Prognostic Indicators and Biomarkers
    1. Elevated IL-6 and TNF-α are Predictors of Respiratory Failure in Severe COVID-19
    2. Increased Neutrophil Activators (G-CSF, IL-8) and Effectors (RETN, LCN2, HGF, MMP8) are Hallmarks of Critical Illness in COVID-19
    3. Type-I Interferon Deficiency (No IFN-β and Low IFN-α) May Be a Hallmark of Severe COVID-19
    4. Calprotectin Levels Appear to Positively Correlate with Disease Severity
    5. Thrombocytopenia Appears to be Associated with Increased Disease Severity and Higher Mortality in COVID-19
    6. Abnormal Liver Tests Occur in Most Hospitalized COVID-19 Patients and May Be Associated with Worse Outcomes
  6. Role of NSAIDS
    1. Use of NSAIDs in Patients with COVID-19 is Safe and Does Not Lead to More Severe Disease

  7. Neuro Involvement
    1. Indirect Neurological Complications (Confusion, Headache, etc.) Are Common; Acute Cerebrovascular Disease and Seizures Due to Dysregulation of Systemic Heomeostasis and Coagulopathy Have Been Observed; There is Little Evidence of Direct Neurological Involvement

  8. GI Involvement
    1. Digestive Symptoms Are Common in COVID-19 and May Be Associated with a Worse Prognosis
    2. Acute Mesenteric Ischemia from Small Vessel Thrombosis and Cholestasis are Common in COVID-19 Inpatients

  9. Dermatologic Involvement
    1. Common Cutaneous Manifestations of COVID-19 Include Chilblain-like, Maculopapular, Vesicular, Urticarial, and Other Lesions and Nondescript Rashes
    2. Cutaneous Lesions are Most Commonly Seen on the Toes, Soles, Fingers, Extremities, and/or Heels (“COVID Toes”)

  10. Chemosensory Dysfunction
    1. Chemosensory Dysfunction, including Anosmia and/or Aeusia, is Strongly Associated with COVID‐19 and May Be Associated with Mild Disease
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