COVID-19 Clinical Resources and Pertinent Research
A daily updated list of the most useful COVID-19 clinical resources and the most significant research publications with a summary of their key findings. To contribute, click the plus button on the left. Short URL: bit.ly/C19Res

Epidemiology and Virology

  1. General Epidemiology
    1. CEBM: Global COVID-19 Case Fatality Rates
    2. Cochrane COVID-19 Reviews of Infection Prevention and Control Measures
    3. Imperial College London Centre for Global Infection Disease Analysis COVID-19 Reports
    4. Recurrent Outbreaks (“Second and Third Waves”) Are Likely
    5. COVID-19 Symptomatic Infection Fatality Rate (IFR-S) in the U.S. is 0.8–1.5% and the Case Fatality Rate (CFR) is ~6%
    6. Seroprevalence of SARS-CoV-2–Specific Antibodies Among Adults Remains Very Low
    7. SARS-COV-2 Clusters Have Been Traced to Parties, Nightclubs, Bars, Karaoke Bars, and Gyms
    8. Testing of Wastewater is Useful in Monitoring and Predicting Infection Rates
    9. Symptom Screening Fails to Identify Most Children with COVID-19 and Asymptomatic and Presymptomatic Children Appear to Shed Virus for 2 to 3 Weeks

  2. Vaccine Development
    1. The Lancet: COVID-19 Vaccine Development Update (June 2020)
    2. NYT Coronavirus Vaccine Tracker
    3. STAT News COVID-19 Vaccine Tracker

  3. Viral Transmission and Shedding
    1. CEBM Papers on the Transmission Dynamics of COVID-19
    2. SARS-CoV-2 is Shed During Respiration, Toileting, and Fomite Contact and Can Be Aerosolized
    3. SARS-CoV-2 Can Remain Viable and Infectious in Aerosols for Hours and on Surfaces for Days
    4. The Mean Incubation Period of COVID-19 is 5 Days
    5. Detection of Viral RNA via PCR Does Not Necessarily Indicate Infectiousness
    6. Viral Load Peaks in the Early Phase with Upper Respiratory Viral Shedding Peaking 4-6 Days After Symptom Onset
    7. SARS-CoV-2 is Transmitted by Asymptomatic and Presymptomatic Individuals
    8. Symptomatic Neonates, Children, and Teenagers Shed Infectious SARS-CoV-2
    9. SARS-CoV-2 is Consistently Found in Stool, Indicating Potential for Fecal-Oral Transmission
    10. No Evidence that Seasonality or Warmer Temperatures Reduce Transmission of SARS-CoV-2
  4. Viral Dynamics and Immune Response
    1. General
    2. Humans Produce Neutralizing Antibodies to SARS-CoV-2
    3. Asymptomatic SARS-CoV-2 Infections May Be Associated with a Weaker Concomitant Immune Response
    4. SARS-CoV-2 T Cell Immunity and Relationship with Neutralization Antibody Titers
    5. Infection with Betacoronaviruses Induces Multispecific and Long-Lasting T Cell Immunity to the Structural Nucleocapsid Protein, that Appears to Neutralize SARS-CoV-2
    6. Natural Passive Immunity without Vertical Transmission Has Been Observed in Several Newborns
    7. Duration of Postinfection Immunity
    8. Incidences of Reinfection

  5. Virology
    1. Genomic Epidemiology of SARS-CoV-2
    2. Molecular Virology
      1. Video Lecture: Molecular Virology of Coronaviruses
      2. Ke Z, et al. Structures and Distributions of SARS-CoV-2 Spike Proteins on Intact Virions. Nature. Aug 2020.
      3. Finkel Y, et al. The Coding Capacity of SARS-CoV-2. Nature. Sep 2020.
      4. Greaney AJ, et al. Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain That Escape Antibody Recognition. Sep 2020. (Not Peer Reviewed)
    3. Potentially Clinically Relevant Mutations in the SARS-CoV-2 Genome (Nature News Summary)
    4. SARS-CoV-2 is Not a Purposefully Manipulated Virus and it’s Lineage has been Circulating in Bats for Decades
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