COVID-19 Clinical Resources and Pertinent Research
A regularly updated list of the most useful COVID-19 clinical resources, the most significant research publications, and reliable news. To contribute, click the plus button on the left. Short URL: bit.ly/C19Res

Epidemiology and Virology

  1. General Epidemiology
    1. CEBM: Global COVID-19 Case Fatality Rates
    2. Cochrane COVID-19 Reviews of Infection Prevention and Control Measures
    3. Imperial College London Centre for Global Infection Disease Analysis COVID-19 Reports
    4. Recurrent Outbreaks (“Second and Third Waves”) Are Likely
    5. Effects of Introducing and Relaxing Non-Pharmaceutical Interventions on SARS-CoV-2 Transmission Are Delayed by 1–3 Weeks
    6. Mask-Wearing, Even with the Use of Non-Medical Masks with Only 20% Efficacy, Substantially Impacts Outbreak Control (Public Health Measures Infographic)
    7. COVID-19 Symptomatic Infection Fatality Rate (IFR-S) in the U.S. is 0.8–1.5% and the Case Fatality Rate (CFR) is ~6%
    8. COVID-19 CFR for Patients Requiring Invasive Mechanical Ventilation is 45%
    9. Seroprevalence of SARS-CoV-2–Specific Antibodies Among Adults Remains Very Low
    10. Greater than 75% of Americans Are at Risk of Severe COVID-19 Based on the Prevalence of Known Comorbidities
    11. SARS-COV-2 Clusters Have Been Traced to Flights, Parties, Nightclubs, Bars, Karaoke Bars, and Gyms
    12. Testing of Wastewater is Useful in Monitoring and Predicting Infection Rates
    13. Symptom Screening Fails to Identify Most Children with COVID-19 and Asymptomatic Children Appear to Shed Viral RNA for 2 to 3 Weeks

  2. Vaccine Development
    1. LSHTM VaC COVID-19 Vaccine Tracker (Explanatory Paper)
    2. Nature – SARS-CoV-2 Vaccines in Development (September 2020)
    3. NYT Coronavirus Vaccine Tracker
    4. STAT News COVID-19 Vaccine Tracker

  3. Viral Transmission and Shedding (Overview)
    1. CEBM Papers on the Transmission Dynamics of COVID-19
    2. SARS-CoV-2 is Shed During Respiration, Toileting, and Fomite Contact and is Commonly Aerosolized (Diagram)
    3. SARS-CoV-2 Can Remain Viable and Infectious in Aerosols for Hours and Viable on Surfaces for Days
    4. The Mean Incubation Period of COVID-19 is 5.7 Days (Diagram)
    5. Detection of Viral RNA via PCR Does Not Necessarily Indicate Infectiousness
    6. Viral Load Peaks in the Early Phase with Upper Respiratory Viral Shedding Peaking 4-6 Days After Symptom Onset; Viral Load May Be Correlated with Severity (Diagram)
    7. SARS-CoV-2 is Transmitted by Presymptomatic and Asymptomatic Individuals
    8. Symptomatic Neonates, Children, and Teenagers Shed Infectious SARS-CoV-2
    9. SARS-CoV-2 RNA Has Been Found in Stool, Indicating the Potential for Fecal-Oral Transmission
    10. Biting Insects Do Not Pose a SARS-CoV-2 Transmission Risk to Humans or Animals
    11. No Evidence that Seasonality or Warmer Temperatures Reduce Transmission of SARS-CoV-2
  4. Viral Dynamics and Immune Response
    1. General (Diagram 1 / Diagram 2 / Diagram 3)
    2. Humans Produce Neutralizing Antibodies to SARS-CoV-2 (Diagram)
    3. The Magnitude of the Neutralizing Antibody Response Appears to Depend on Disease Severity
    4. Duration and Natural Decline of Neutralizing Antibody Response
    5. SARS-CoV-2 T Cell Immunity (Diagram 1 / Diagram 2)
    6. Infection with Betacoronaviruses Appears to Induce Multispecific and Long-Lasting T Cell Immunity to the Structural Nucleocapsid Protein, that Appears to Neutralize SARS-CoV-2; Antibodies Not Cross Reactive
    7. Natural Passive Immunity without Vertical Transmission Has Been Observed in Several Newborns
    8. Select Case Reports of Reinfection

  5. Virology
    1. Genomic Epidemiology of SARS-CoV-2
    2. Molecular Virology
      1. Video Lecture: Molecular Virology of Coronaviruses
      2. Ke Z, et al. Structures and Distributions of SARS-CoV-2 Spike Proteins on Intact Virions. Nature. Aug 2020.
      3. Finkel Y, et al. The Coding Capacity of SARS-CoV-2. Nature. Sep 2020.
      4. Greaney AJ, et al. Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain That Escape Antibody Recognition. Sep 2020. (Not Peer Reviewed)
    3. Clinically Relevant Mutations in the SARS-CoV-2 Genome
    4. Zoonosis
    5. SARS-CoV-2 is Not a Purposefully Manipulated Virus and it’s Lineage has been Circulating in Bats for Decades
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