COVID-19 Clinical Resources and Pertinent Research
A daily updated list of the most useful COVID-19 clinical resources and the most significant research publications with a summary of their key findings. To contribute, click the plus button on the left. Short URL: bit.ly/C19Res

Treatment and Management Research

  1. Resources
    1. Assessment of Evidence for COVID-19-Related Pharmacological Treatments
    2. JAMA Review: Pathophysiology, Transmission, Diagnosis, and Treatment of COVID-19
    3. UW COVID-19 Treatment, Trails, and Teaching Guide
    4. BMJ Drug Treatments for COVID-19: Living Systematic Review and Network Meta-Analysis
    5. Global Coronavirus COVID-19 Clinical Trial Tracker

  2. Clinical Management
    1. Intensive Care Management of COVID-19: Challenges and Recommendations
    2. Systemic Anticoagulation May Imrpove Survival in COVID-19
    3. Pathogenesis and Treatment of Cytokine Storm in COVID-19
    4. Prone Positioning May Improve Oxygenation in Select Patients
  3. Convalescent Plasma
    1. Preliminary Findings – No Reduction in Mortality or Progression to Severe Disease

  4. Pharmacological Treatments
    1. Corticosteroids
      1. Clinical Trials
      2. There is Mixed Evidence on the Limited Efficacy of Corticosteroids to Reduce Mortality in Severe COVID-19
      3. Corticosteroids May Increase Mortality in COVID-19 Patients with a History of Asthma
    2. Tocilizumab
      1. Clinical Trials
      2. COVACTA Trial: No Improvement in Clinical Status of COVID-19 Associated Pneumonia or Reduction of Mortality (Roche Press Release)
      3. Tocilizumab Administration Appears to Reduce Mortality in Critically Ill COVID-19 Patients
    3. Remdesivir
      1. Clinical Trials (More Info)
      2. Expanded Access Treatment Protocol
      3. Remdesivir Does Not Appear to Improve Clinical Status or Outcome in COVID-19 but May Shorten Time to Recovery
    4. Favipiravir
      1. Clinical Trials
      2. Preliminary Findings:
    5. Lopinavir–Ritonavir
      1. Clinical Trials
      2. Preliminary Findings:
    6. Famotidine
      1. Clinical Trials
      2. Preliminary Findings:
    7. Hydroxychloroquine / Chloroquine
      1. Contextual Commentary: Of Chloroquine and COVID-19
          In past research, chloroquine has shown in vitro activity against many different viruses, but no benefit in animal models. Chloroquine has been proposed several times for the treatment of acute viral diseases in humans without success.
      2. Hydroxychloroquine and Cholorquine are Ineffective as Prophylaxis for or the Treatment of COVID-19 and are Cardiotoxic
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1 Response

  1. Munir Hazbun MD says:

    Our published report support the use of Methylprednisolone in severe COVID 19 respiratory failure. We learned that higher doses allowed to rescued several patients. We have not need prone position since. The illness is protracted but with a mortality of about 15% with comprehensive care that is broad, including anti-coagulation, lung recruitment strategies among state of the art critical care .
    https://journals.lww.com/ccejournal/pages/articleviewer.aspx?year=2020&issue=06000&article=00023&type=Fulltext&context=LatestArticles

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